lipids in mRNA vaccine The mRNA vaccine contains 2 core components, the Lipid Nanoparticle (LNP) wraps the core mRNA (~4.18kb). Upon intramuscular injection, the mRNAs were taken by the immune cells and translate into covid-19 (NC_045512.2) spike protein. Both Pfizer and Moderna encodes 100% identical full length (NC_045512.2) spike protein, b...

Thinking about the algorithms in packages before running the code With the development of the NGS field , now there are tons of bioinformatics packages available for data analysis. There are a lot package choices for each step of the NGS analysis. For example, tons of short sequence alignment algorithms have been developed to meet the requireme...

Covid19 seq approches

Signal and Noise When I took the biostatistical course given by Dr. Thomas Love a few years ago, he recommended us reading a seemingly unrelavent stastical book “ The signal and the noise” by Nate Silver. The book is great and uncovers the promises and pitfalls of the big data analysis, one of the biggest pitfalls is that in most times what we...

Coming Therapies John Carroll at Endpoint recently selected 11 potential companies for near future “The Endpoints 11: A group of disruptive upstarts on a do-or-die mission to launch new meds”. Including Arrakis that I previously mentioned, Moderna’s potent rival BioNTech, see full list below. Arrakis Therapeutics Autolus BioNTech Cod...